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Polynucleotides

Cellular repair and regeneration for face, under-eye, or both combined in one appointment. Single sessions or course of 3.

What polynucleotides do

Polynucleotide bio-stimulators are short DNA fragments that act as a signal to your skin to repair itself. Once injected, they stimulate fibroblast activity (the cells that make collagen and elastin), reduce inflammation, and support the skin's own regenerative process.

They are not fillers. They don't add volume or change shape. They work on the quality and resilience of the skin itself — particularly useful for areas where the skin is thin, damaged or struggling to repair on its own.

Polynucleotides treatment
How it works
1
DNA-fragment signals

Purified polynucleotides (short DNA fragments) are injected into the dermis, where they act as biological signals to the surrounding cells.

2
Fibroblasts activate

The signals stimulate fibroblast activity, reduce inflammation and trigger the skin's own regenerative pathways across the treated area.

3
Tissue rebuilds

Over four to six weeks the underlying skin structure repairs. Best results come from a course of three sessions spaced two to three weeks apart.

Best for

  • Dark circles & under-eye hollows
  • Acne scarring & uneven texture
  • Sun-damaged or compromised skin
  • Fine lines and crepiness
  • Post-laser or post-microneedling recovery
  • Thin, fragile skin

Pricing

Polynucleotides pricing

Single treatments or course of 3. The combined face-and-eyes appointment treats both areas in one session.

Under Eye

Cellular repair for the delicate tear-trough and lower-eyelid area. Specialist formulation for thin skin.

Face

Cellular repair and skin-quality treatment across the full face. The standard polynucleotides protocol.

Combined Face & Eyes

Both areas treated in a single appointment. One visit, one recovery, lower total than separate sessions.

Single session
No commitment — pay per session
£490
Course of 3
Save £120 · £450 per session
Recommended
£1,350
was £1,470
Not sure which to book? A consultation establishes whether face, under-eye, or combined is right for your skin and goals.

What happens at your session

Duration
30–45 minutes
Pain level
Low — fine needles
Downtime
None — mild redness
Numbing
Topical, on request
Sessions
3 sessions, 2–4 weeks apart
Results in
8–12 weeks (build gradually)
Lasts
6–9 months
Maintenance
Single session every 3 months

Results

Before & after

Real results from real polynucleotides clients. All photos used with written consent. Lighting and pose matched between shots.

Polynucleotides before — Under-eye correction
Polynucleotides after — Under-eye correction
Polynucleotides before — Acne scarring — cheek area
Polynucleotides after — Acne scarring — cheek area
Polynucleotides before — Sun damage — full face
Polynucleotides after — Sun damage — full face
Polynucleotides before — Fine line reduction — eye area
Polynucleotides after — Fine line reduction — eye area

Individual results vary. Injectable results build gradually — the photos above show the visible improvement at the end of the recommended course. Consultation determines whether you're a good candidate.


Verified reviews

What our clients say

Reviews from real polynucleotides clients at Peonella, posted to Fresha and Google.

★★★★★

"Had been considering tear-trough filler for years and was scared of it. The polynucleotides under-eye course was so much gentler — my dark circles are properly improved and I look rested."

JH
Jenny H.
Polynucleotides under-eye · Course of 3 · Sandhurst
★★★★★

"My skin had been so battered by sun damage from years of holidays. Three sessions and the texture is genuinely different. Worth every penny."

NL
Nadia L.
Polynucleotides full-face · Course of 3
★★★★★

"Had this for post-acne scarring and the difference is noticeable. Liudmyla explained the science properly — felt confident throughout."

CD
Claire D.
Polynucleotides · Course of 3 · Crowthorne

Polynucleotides — common questions

How are these different from filler?

Filler adds volume to a specific area. Polynucleotides don't add anything — they stimulate your skin's own repair process. There's no "filler look" or volume change. The improvement is in skin quality.

What are they made from?

Polynucleotides are short DNA fragments derived from purified marine sources — the molecules are biocompatible with human tissue, which is why they work so well. The active ingredient is the DNA fragments themselves, not any protein, so allergy risk is extremely low. We screen for it at consultation either way.

Will they fix my dark circles?

Polynucleotides under-eye are often the right call for genuine tear-trough hollows, thin under-eye skin, and pigmentation contributed by skin thinning. They won't fix dark circles caused purely by sleep, blood vessels, or pigmentation — we'll be honest at consultation.

Why 3 sessions?

Polynucleotides work through cumulative stimulation. One session shows mild improvement; three sessions across 2–4 weeks each is what produces the visible repair. Single sessions are useful for top-up after a course.

Can I combine with Profhilo?

Yes — they target different things. Some clients have polynucleotides for repair (e.g. under-eye), then Profhilo for general hydration. We plan timing at consultation to give each its space.

Am I a good candidate?

Most healthy adults are. We rule out pregnancy, breastfeeding, active autoimmune flare, current acute illness, and confirmed allergy to the product. Full screening at consultation.

Ready when you are

Book your polynucleotides consultation

30 minutes with our lead practitioner. Skin assessment, medical history, honest recommendation. £30 — fully credited back at your first session.

Book a Consultation — £30 credited back → Compare Injectables →
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